μ-Suppression during Action Observation and Execution Correlates with BOLD in Dorsal Premotor, Inferior Parietal, and SI Cortices

被引:196
作者
Arnstein, Dan [2 ]
Cui, Fang [1 ,2 ]
Keysers, Christian [1 ,2 ]
Maurits, Natasha M. [3 ]
Gazzola, Valeria [1 ,2 ]
机构
[1] Royal Netherlands Acad Arts & Sci, Netherlands Inst Neurosci, NL-1105 BA Amsterdam, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Neurosci, NL-9713 GZ Groningen, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, NL-9713 GZ Groningen, Netherlands
关键词
MIRROR NEURON SYSTEM; HUMAN BRAIN; ACTION RECOGNITION; FMRI DATA; MOTOR; MOVEMENT; RHYTHMS; CORTEX; ARTIFACT; AREAS;
D O I
10.1523/JNEUROSCI.0963-11.2011
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
The discovery of mirror neurons in the monkey, that fire during both the execution and the observation of the same action, sparked great interest in studying the human equivalent. For over a decade, both functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) have been used to quantify activity in the human mirror neuron system (MNS)-yet, little is still known about how fMRI and EEG measures of the MNS relate to each other. To test the frequent assumption that regions of the MNS as evidenced by fMRI are the origin of the suppression of the EEG mu-rhythm during both action execution and observation, we recorded EEG and BOLD-fMRI signals simultaneously while participants observed and executed actions. We found that the suppression of the mu-rhythm in EEG covaried with BOLD activity in typical MNS regions, inferior parietal lobe (IPL), dorsal premotor (dPM) and primary somatosensory cortex (BA2), during both action observation and execution. In contrast, in BA44, only nonoverlapping voxels correlated with mu-suppression during observation and execution. These findings provide direct support for the notion that mu-suppression is a valid indicator of MNS activity in BA2, IPL, and dPM, but argues against the idea that mirror neurons in BA44 are the prime source of mu-suppression. These results shed light on the neural basis of mu-suppression and provide a basis for integrating more closely the flourishing but often separate literatures on the MNS using fMRI and EEG.
引用
收藏
页码:14243 / 14249
页数:7
相关论文
共 48 条
[1]
Identification of EEG events in the MR scanner: The problem of pulse artifact and a method for its subtraction [J].
Allen, PJ ;
Polizzi, G ;
Krakow, K ;
Fish, DR ;
Lemieux, L .
NEUROIMAGE, 1998, 8 (03) :229-239
[2]
A method for removing imaging artifact from continuous EEG recorded during functional MRI [J].
Allen, PJ ;
Josephs, O ;
Turner, R .
NEUROIMAGE, 2000, 12 (02) :230-239
[3]
Action observation activates premotor and parietal areas in a somatotopic manner: an fMRI study [J].
Buccino, G ;
Binkofski, F ;
Fink, GR ;
Fadiga, L ;
Fogassi, L ;
Gallese, V ;
Seitz, RJ ;
Zilles, K ;
Rizzolatti, G ;
Freund, HJ .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 13 (02) :400-404
[4]
Actor's and observer's primary motor cortices stabilize similarly after seen or heard motor actions [J].
Caetano, Gina ;
Jousmaki, Veikko ;
Hari, Riitta .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (21) :9058-9062
[5]
Action observation and acquired motor skills:: An fMRI study with expert dancers [J].
Calvo-Merino, B ;
Glaser, DE ;
Grèzes, J ;
Passingham, RE ;
Haggard, P .
CEREBRAL CORTEX, 2005, 15 (08) :1243-1249
[6]
ALE meta-analysis of action observation and imitation in the human brain [J].
Caspers, Svenja ;
Zilles, Karl ;
Laird, Angela R. ;
Eickhoff, Simon B. .
NEUROIMAGE, 2010, 50 (03) :1148-1167
[7]
Neural correlates of mental rehearsal in dorsal premotor cortex [J].
Cisek, P ;
Kalaska, JF .
NATURE, 2004, 431 (7011) :993-996
[8]
Brain areas selective for both observed and executed movements [J].
Dinstein, Ilan ;
Hasson, Uri ;
Rubin, Nava ;
Heeger, David J. .
JOURNAL OF NEUROPHYSIOLOGY, 2007, 98 (03) :1415-1427
[9]
Normal Movement Selectivity in Autism [J].
Dinstein, Ilan ;
Thomas, Cibu ;
Humphreys, Kate ;
Minshew, Nancy ;
Behrmann, Marlene ;
Heeger, David J. .
NEURON, 2010, 66 (03) :461-469
[10]
Testing Simulation Theory with Cross-Modal Multivariate Classification of fMRI Data [J].
Etzel, Joset A. ;
Gazzola, Valeria ;
Keysers, Christian .
PLOS ONE, 2008, 3 (11)