Role of the Bloom's syndrome helicase in maintenance of genome stability

被引：28

作者：

Hickson, ID ^{[1
]}

Davies, SL ^{[1
]}

Li, JL ^{[1
]}

Levitt, NC ^{[1
]}

Mohaghegh, P ^{[1
]}

North, PS ^{[1
]}

Wu, L ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Inst Mol Med, Imperial Canc Res Fund Labs, Oxford OX3 9DS, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2001年 / 29卷

关键词：

cancer; genetic recombination; RecQ helicase; topoisomerase;

D O I：

10.1042/BST0290201

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The RecQ family of DNA helicases has members in all organisms analysed. In humans, defects in three family members are associated with disease conditions: BLM is defective in Bloom's syndrome, WRN in Werner's syndrome and RTS in Rothmund-Thomson syndrome. In each case, cells from affected individuals show inherent genomic instability. The focus of our work is the Bloom's syndrome gene and its product, BLM. Here, Re review the latest information concerning the roles of BLM in the maintenance of genome integrity.

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收藏

页码：201 / 204

页数：4

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