Rabies Virus Transcription and Replication

被引：108

作者：

Albertini, Aurelie A. V. ^{[1
]}

Ruigrok, Rob W. H. ^{[2
]}

Blondel, Danielle ^{[1
]}

机构：

[1] CNRS, UPR 3296, Gif Sur Yvette, France

[2] UJF EMBL CNRS, Unit Virus Host Cell Interact, UMI 3265, Grenoble, France

来源：

ADVANCES IN VIRUS RESEARCH: RESEARCH ADVANCES IN RABIES, VOL 79 | 2011年 / 79卷

关键词：

VESICULAR STOMATITIS-VIRUS; NUCLEOPROTEIN-RNA COMPLEX; NUCLEOCAPSID PROTEIN-N; CRYSTAL-STRUCTURE; GENOME SEQUENCE; MATRIX PROTEIN; LYSSAVIRUS PHOSPHOPROTEIN; POLYMERASE COFACTOR; ELECTRON-MICROSCOPY; GENE-EXPRESSION;

D O I：

10.1016/B978-0-12-387040-7.00001-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Rabies virus (RABV) is a negative-stranded RNA virus. Its genome is tightly encapsidated by the viral nucleoprotein (N) and this RNA-N complex is the template for transcription and replication by the viral RNA-dependent RNA polymerase (L) and its cofactor, the phosphoprotein (P). We present molecular, structural, and cellular aspects of RABV transcription and replication. We first summarize the characteristics and molecular biology of both RNA synthesis processes. We then discuss biochemical and structural data on the viral proteins (N, P, and L) and their interactions with regard to their role in viral transcription and replication. Finally, we review evidence that rabies viral transcription and replication take place in cytoplasmic inclusion bodies formed in RABV-infected cells and discuss the role of this cellular compartmentalization.

引用

页码：1 / 22

页数：22

共 71 条

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