Approach to the treatment of multiple myeloma: a clash of philosophies

被引：104

作者：

Rajkumar, S. Vincent ^{[1
]}

Gahrton, Gosta ^{[2
]}

Bergsagel, P. Leif ^{[3
]}

机构：

[1] Mayo Clin, Coll Med, Div Hematol, Rochester, MN 55905 USA

[2] Karolinska Inst, Stockholm, Sweden

[3] Mayo Clin, Div Hematol & Oncol, Scottsdale, AZ USA

来源：

BLOOD | 2011年 / 118卷 / 12期

关键词：

STEM-CELL TRANSPLANTATION; LENALIDOMIDE PLUS DEXAMETHASONE; BONE-MARROW-TRANSPLANTATION; HIGH-DOSE THERAPY; COMPLETE RESPONSE; CLINICAL-TRIALS; PHASE-III; MONOCLONAL GAMMOPATHY; COMBINATION THERAPY; MEDICAL ONCOLOGY;

D O I：

10.1182/blood-2011-06-297853

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

In this Perspective, we summarize some of the most contentious issues surrounding diagnosis and treatment of myeloma. We outline how a fundamental clash of philosophies, cure versus control, may be at the heart of many of the controversies. From the very definition of the disease to risk stratification to the validity of current clinical trial endpoints, we highlight the major areas of debate and provide alternative viewpoints that have implications for trial design and interpretation, as well as clinical practice. (Blood. 2011;118(12):3205-3211)

引用

页码：3205 / 3211

页数：7

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