Inflammatory reactions in progressive multifocal leukoencephalopathy after highly active antiretroviral therapy

被引：78

作者：

Miralles, P ^{[1
]}

Berenguer, J

Lacruz, C

Cosín, J

López, JC

Padilla, B

Muñoz, L

Garcia-de-Viedma, D

机构：

[1] Hosp Gen Gregorio Maranon, Clin Microbiol & Infect Dis Serv, Madrid, Spain

[2] Hosp Gen Gregorio Maranon, Pathol Serv, Madrid, Spain

[3] Hosp Gen Gregorio Maranon, Serv Radiol, Madrid, Spain

来源：

AIDS | 2001年 / 15卷 / 14期

关键词：

D O I：

10.1097/00002030-200109280-00028

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Three patients with progressive multifocal leukoencephalopathy (PML) treated with highly active antiretroviral therapy (HAART) worsened clinically and radiologically. At the time of deterioration all three had reduced HIV viraemia and increased CD4 cell counts. Brain biopsy in all three disclosed PML and marked perivascular lymphoplasmacytic infiltration. We reviewed the slides of 28 brain biopsies diagnostic of PML. Inflammatory changes were observed in four out of nine patients on HAART and in one out of 19 patients not on HAART.

引用

页码：1900 / 1902

页数：3

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