G-308A TNF-α polymorphism is associated with an increased risk of invasive cervical cancer

被引：87

作者：

Duarte, I ^{[1
]}

Santos, A

Sousa, H

Catarino, R

Pinto, D

Matos, A

Pereira, D

Moutinho, J

Canedo, P

Machado, JC

Medeiros, R

机构：

[1] Portuguese Inst Oncol, Oncol Mol Lab, Oporto, Portugal

[2] Portuguese Inst Oncol, Dept Gynaecol, Oporto, Portugal

[3] Univ Porto, IPATIMUP, Inst Mol Pathol & Immunol, P-4100 Oporto, Portugal

[4] Univ Porto, Fac Med, P-4100 Oporto, Portugal

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 334卷 / 02期

关键词：

tumor necrosis factor-alpha; -308 promoter polymorphism; cervical cancer; human papillomavirus;

D O I：

10.1016/j.bbrc.2005.06.137

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cervical cancer is initiated by high-risk human papillomaviruses (HPV-16 and HPV-18), but an effective immune response may control the progression of this disease. Tumor necrosis factor-alpha (TNF-alpha) is a pro-inflammatory cytokine, that has been implicated in several cancers. In a case-control study, we evaluated the association between the G-308A TNF-alpha promoter polymorphism and the risk for invasive cervical cancer (ICC). TNF-alpha polymorphism was analyzed by PCR-RFLP and confirmed by sequencing. DNA was obtained from blood samples of 439 individuals, including 195 patients with ICC and 244 normal healthy controls. According to our results, women carrying the A allele present a twofold increased risk of developing ICC) = 0.006; OR = 1.88; 95% Cl [1.20-2.94]). In conclusion, our study suggests that the presence of the high producer allele -308A in the TNF-alpha gene appears to be associated with an increased risk for the development of ICC. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：588 / 592

页数：5

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