A new class of "tethered" ruthenium(II) catalyst for asymmetric transfer hydrogenation reactions

被引：255

作者：

Hannedouche, J

Clarkson, GJ

Wills, M ^{[1
]}

机构：

[1] Univ Warwick, Asymmetr Catalysis Grp, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] Univ Warwick, Xray Crystallog Unit, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 04期

关键词：

D O I：

10.1021/ja0392768

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ruthenium dimer 4 is converted directly to monomeric asymmetric transfer hydrogenation catalyst 2 under the conditions employed for ketone reduction. Using 0.25 mol % of either 4 or 0.5 mol % of 2 in formic acid/triethylamine, it is possible to achieve ketone reduction in quantitative conversion and with ee's as high as 98%. Complex 2 is a robust "single-reagent" catalyst which offers significant scope for modification toward specific substrates. The synthesis and applications of an analogous complex derived from (1R,2S)-norephedrine are also described. Copyright © 2004 American Chemical Society.

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页码：986 / 987

页数：2

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