Neuroscience and hormesis: Overview and general findings

被引：94

作者：

Calabrese, Edward J. ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Publ Hlth Environm Hlth Sci, Amherst, MA 01003 USA

来源：

CRITICAL REVIEWS IN TOXICOLOGY | 2008年 / 38卷 / 04期

关键词：

addiction; Alzheimer's disease; anxiolytic; bell-shaped; biphasic neuroprotection; dose-response; hormesis; pain; p-glycoprotein; seizures; stroke; U-shaped; Yerkes-Dodson law;

D O I：

10.1080/10408440801981957

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

This article provides a summary of an assessment of the occurrence and impact of hormesis in the neurosciences, including the areas of neuroprotection, neurite outgrowth, and drugs for Alzheimer's disease, Parkinson's disease, anxiety, pain, seizures, stroke, as well as in the areas of behavioral pharmacology, addictive drugs, stress biology including the Yerkes-Dodson law, and p-glycoprotein efflux activity. The findings indicate that the hormetic dose response has a common, if not dominant, presence in each of these diverse areas of neuroscience and further strengthens the conclusion that hormesis is highly generalizable, being independent of biological model, endpoint, and chemical class.

引用

页码：249 / 252

页数：4

共 17 条

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