Effects of amide constituents from pepper on adipogenesis in 3T3-L1 cells

被引：32

作者：

Zhang, Hailong ^{[1
]}

Matsuda, Hisashi ^{[1
]}

Nakamura, Seikou ^{[1
]}

Yoshikawa, Masayuki ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 11期

关键词：

Piper chaba; amide constituents; retrofractamide A; 3T3-L1; cells; adipogenesis; adiponectin;

D O I：

10.1016/j.bmcl.2008.04.052

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Several amide constituents (piperlonguminine and retrofractamides A, B, and C) from the fruit of Piper chaba promoted adipogenesis of 3T3-L1 cells. Among them, retrofractamide A was the most active and significantly increased the amount of adiponectin released into the medium and the uptake of 2-deoxyglucose into the cells. Retrofractamide A also increased mRNA levels of adiponectin, peroxisome proliferator-activated receptor gamma 2 (PPAR gamma 2), glucose transporter 4 (GLUT4), and insulin receptor substrate 1 (IRS-1), but did not act as a PPAR gamma agonist different from troglitazone. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3272 / 3277

页数：6

共 26 条

[1]

Adiponectin inhibits LPS-induced NF-κB activation and IL-6 production and increases PPARγ2 expression in adipocytes [J].

Ajuwon, KM ;

Spurlock, ME .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2005, 288 (05) :R1220-R1225

[2]

Characteristics of circadian gene expressions in mice white adipose tissue and 3T3-L1 adipocytes [J].

Aoyagi, T ;

Shimba, S ;

Tezuka, M .

JOURNAL OF HEALTH SCIENCE, 2005, 51 (01) :21-32

[3]

Ginsenoside 20(S)-protopanaxatriol (PPT) activates peroxisome proliferator-activated receptor γ (PPARγ) in 3T3-L1 adipocytes [J].

Han, KL ;

Jung, MH ;

Sohn, JH ;

Hwang, JK .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, 29 (01) :110-113

[4]

Henness Sheridan, 2007, Curr Opin Endocrinol Diabetes Obes, V14, P166, DOI 10.1097/01.med.0000261735.91562.06

[5]

Effects of capsaicin on induction of apoptosis and inhibition of adipogenesis in 3T3-L1 cells [J].

Hsu, Chin-Lin ;

Yen, Gow-Chin .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2007, 55 (05) :1730-1736

[6]

Adiponectin and adiponectin receptors [J].

Kadowaki, T ;

Yamauchi, T .

ENDOCRINE REVIEWS, 2005, 26 (03) :439-451

[7]

Matsuda H., 2005, Journal of Traditional Medicines, V22, P145

[8]

Protective effects of amide constituents from the fruit of Piper chaba on D-galactosamine/TNF-α-induced cell death in mouse hepatocytes [J].

Matsuda, Hisashi ;

Ninomiya, Kiyofumi ;

Morikawa, Toshio ;

Yasuda, Daisuke ;

Yamaguchi, Itadaki ;

Yoshikawa, Masayuki .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (06) :2038-2042

[9]

Adipocytes with increased hexosamine flux exhibit insulin resistance, increased glucose uptake, and increased synthesis and storage of lipid [J].

McClain, DA ;

Hazel, M ;

Parker, G ;

Cooksey, RC .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2005, 288 (05) :E973-E979

[10]

Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1) [J].

McNamara, FN ;

Randall, A ;

Gunthorpe, MJ .

BRITISH JOURNAL OF PHARMACOLOGY, 2005, 144 (06) :781-790

← 1 2 3 →