New genotype of avian influenza H5N1 viruses isolated from tree sparrows in China

被引:80
作者
Kou, Z
Lei, FM [1 ]
Yu, J
Fan, ZJ
Yin, ZH
Jia, CX
Xiong, KJ
Sun, YH
Zhang, XW
Wu, XM
Gao, XB
Li, TX
机构
[1] Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China
[2] Chinese Acad Sci, Inst Zool, Beijing 100080, Peoples R China
[3] Chinese Acad Sci, Beijing Genom Inst, Beijing 101300, Peoples R China
[4] Shaanxi Inst Zool, Xian 710032, Peoples R China
关键词
D O I
10.1128/JVI.79.24.15460-15466.2005
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The 2004 outbreaks of highly pathogenic avian influenza H5N1 disease in China led to a great poultry loss and society attention. A survey of avian influenza viruses was conducted on tree sparrows (Passer montanus) collected in China in 2004. Four viruses were isolated from free-living tree sparrows. The results of the whole-genome analysis indicated that an H5N1 virus with a new genotype is circulating among tree sparrows. The hemagglutinin and neuraminidase genes of the new genotype were derived from Gs/Gd/96-like viruses and the nuclear protein gene descended from the 2001 genotype A H5N1 viruses, while the other inner genes originated from an unknown influenza virus. In experimental infection, all four viruses were highly pathogenic to chickens but not pathogenic to ducks or mice. The four tree sparrow viruses were different from the 2003 tree sparrow strain (genotype Z) in Hong Kong. The results suggested that H5N1 viruses might be distributed widely in tree sparrows.
引用
收藏
页码:15460 / 15466
页数:7
相关论文
共 24 条
[1]  
Centers for Disease Control and Prevention (CDC), 2004, MMWR Morb Mortal Wkly Rep, V53, P100
[2]   Molecular evolution of H6 influenza viruses from poultry in southeastern China: Prevalence of H6N1 influenza viruses possessing seven A/Hong Kong/156/97 (H5N1)-like genes in poultry [J].
Chin, PS ;
Hoffmann, E ;
Webby, R ;
Webster, RG ;
Guan, Y ;
Peiris, M ;
Shortridge, KF .
JOURNAL OF VIROLOGY, 2002, 76 (02) :507-516
[3]   Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus [J].
Claas, ECJ ;
Osterhaus, ADME ;
van Beek, R ;
De Jong, JC ;
Rimmelzwaan, GF ;
Senne, DA ;
Krauss, S ;
Shortridge, KF ;
Webster, RG .
LANCET, 1998, 351 (9101) :472-477
[4]   Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome. [J].
Fouchier, RAM ;
Schneeberger, PM ;
Rozendaal, FW ;
Broekman, JM ;
Kemink, SAG ;
Munstert, V ;
Kuiken, T ;
Rimmelzwaan, GF ;
Schutten, M ;
van Doornum, GJJ ;
Koch, G ;
Bosman, A ;
Koopmans, M ;
Osterhaus, ADME .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (05) :1356-1361
[5]   Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR [J].
Guan, Y ;
Peiris, JSM ;
Lipatov, AS ;
Ellis, TM ;
Dyrting, KC ;
Krauss, S ;
Zhang, LJ ;
Webster, RG ;
Shortridge, KF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (13) :8950-8955
[6]   Molecular characterization of H9N2 influenza viruses: Were they the donors of the "internal" genes of H5N1 viruses in Hong Kong? [J].
Guan, Y ;
Shortridge, KF ;
Krauss, S ;
Webster, RG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (16) :9363-9367
[7]   X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs [J].
Ha, Y ;
Stevens, DJ ;
Skehel, JJ ;
Wiley, DC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (20) :11181-11186
[8]   Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses [J].
Hatta, M ;
Gao, P ;
Halfmann, P ;
Kawaoka, Y .
SCIENCE, 2001, 293 (5536) :1840-1842
[9]   Avian influenza A (H5N1) in 10 patients in Vietnam. [J].
Hien, TT ;
Liem, NT ;
Dung, NT ;
San, LT ;
Mai, PP ;
Chau, NVV ;
Suu, PT ;
Dong, VC ;
Mai, LTQ ;
Thi, NT ;
Khoa, DB ;
Phat, LP ;
Truong, NT ;
Long, HT ;
Tung, CV ;
Giang, LT ;
Tho, ND ;
Nga, LH ;
Tien, NTK ;
San, LH ;
Tuan, LV ;
Dolecek, C ;
Thanh, TT ;
de Jong, M ;
Schultsz, C ;
Cheng, P ;
Lim, W ;
Horby, P ;
Farrar, J .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (12) :1179-1188
[10]   Universal primer set for the full-length amplification of all influenza A viruses [J].
Hoffmann, E ;
Stech, J ;
Guan, Y ;
Webster, RG ;
Perez, DR .
ARCHIVES OF VIROLOGY, 2001, 146 (12) :2275-2289