Do peptides control their own birth and death?

被引：15

作者：

Fåhraeus, R ^{[1
]}

机构：

[1] Hop St Louis, INSERM, U716, Inst Pharmacol, F-75010 Paris, France

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 03期

关键词：

D O I：

10.1038/nrm1590

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The tumour suppressor protein p53 and the Epstein - Barr- virus- encoded Epstein - Barr virus nuclear antigen-1 (EBNA1) can regulate their own proteasomal degradation and mRNA translation - in effect, they mediate control of their own steady-state levels. A large fraction of mRNA-translation-initiation events does not give rise to functional proteins; so could this reflect a more widespread concept by which certain proteins that require tight control of expression use similar means of self-regulation?

引用

页码：263 / 267

页数：5

共 35 条

[1] Human CD8+ T cell responses to EBV EBNA1:: HLA class I presentation of the (Gly-Ala)-containing protein requires exogenous processing [J].

Blake, N ;

Lee, S ;

Redchenko, I ;

Thomas, W ;

Steven, N ;

Leese, A ;

Steigerwald-Mullen, P ;

Kurilla, MG ;

Frappier, L ;

Rickinson, A .

IMMUNITY, 1997, 7 (06) :791-802

[2] Hypophosphorylation of Mdm2 augments p53 stability [J].

Blattner, C ;

Hay, T ;

Meek, DW ;

Lane, DP .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (17) :6170-6182

[3] P53 IS COVALENTLY LINKED TO 5.8S RIBOSOMAL-RNA [J].

FONTOURA, BMA ;

SOROKINA, EA ;

DAVID, E ;

CARROLL, RB .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (11) :5145-5151

[4] Cytoplasmic p53 polypeptide is associated with ribosomes [J].

Fontoura, BMA ;

Atienza, CA ;

Sorokina, EA ;

Morimoto, T ;

Carroll, RB .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (06) :3146-3154

[5] Control of neuronal size homeostasis by trophic factor-mediated coupling of protein degradation to protein synthesis [J].

Franklin, JL ;

Johnson, EM .

JOURNAL OF CELL BIOLOGY, 1998, 142 (05) :1313-1324

[6] Participation of the human p53 3'UTR in translational repression and activation following gamma-irradiation [J].

Fu, LN ;

Benchimol, S .

EMBO JOURNAL, 1997, 16 (13) :4117-4125

[7] Translational regulation of human p53 gene expression [J].

Fu, LN ;

Minden, MD ;

Benchimol, S .

EMBO JOURNAL, 1996, 15 (16) :4392-4401

[8] Mdm2 promotes the rapid degradation of p53 [J].

Haupt, Y ;

Maya, R ;

Kazaz, A ;

Oren, M .

NATURE, 1997, 387 (6630) :296-299

[9] Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 [J].

Honda, R ;

Tanaka, H ;

Yasuda, H .

FEBS LETTERS, 1997, 420 (01) :25-27

[10] Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53 [J].

Honda, R ;

Yasuda, H .

EMBO JOURNAL, 1999, 18 (01) :22-27

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