Comparison of clinical benefits of clopidogrel therapy in patients with acute coronary syndromes taking atorvastatin versus other statin therapies

被引:129
作者
Wienbergen, H
Gitt, AK
Schiele, R
Juenger, C
Heer, T
Meisenzahl, C
Limbourg, P
Bossaller, C
Senges, J
机构
[1] Herzzentrum Ludwigshafen, D-67063 Ludwigshafen, Germany
[2] Robert Koch Krankenhaus, Gehrden, Germany
关键词
D O I
10.1016/S0002-9149(03)00626-X
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In clinical practice, we found no significant difference between atorvastatin therapy or other statin therapies in the clinical outcomes of patients with acute coronary syndromes receiving clopidogrel therapy. In patients receiving atorvastatin therapy, clopidogrel therapy was associated with a significant decrease in mortality and stroke during univariate analysis and a moderate trend of reduced mortality and stroke without statistical significance in the multivariate analysis. (C)2003 by Excerpta Medica, Inc.
引用
收藏
页码:285 / 288
页数:4
相关论文
共 9 条
  • [1] Management of acute coronary syndromes:: acute coronary syndromes without persistent ST segment elevation -: Recommendations of the Task Force of the European Society of Cardiology
    Bertrand, ME
    Simoons, ML
    Fox, KAA
    Wallentin, LC
    Hamm, CW
    McFadden, E
    De Feyter, PJ
    Specchia, G
    Ruzyllo, W
    [J]. EUROPEAN HEART JOURNAL, 2000, 21 (17) : 1406 - 1432
  • [2] The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin
    Clarke, TA
    Waskell, LA
    [J]. DRUG METABOLISM AND DISPOSITION, 2003, 31 (01) : 53 - 59
  • [3] GITT AK, 2001, EUR HEART J SUPPL, V22, P3276
  • [4] Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation - A new drug-drug interaction
    Lau, WC
    Waskell, LA
    Watkins, PB
    Neer, CJ
    Horowitz, K
    Hopp, AS
    Tait, AR
    Carville, DGM
    Guyer, KE
    Bates, ER
    [J]. CIRCULATION, 2003, 107 (01) : 32 - 37
  • [5] Lau WC, 2000, CIRCULATION, V102, P429
  • [6] Rustige J, 1997, EUR HEART J, V18, P1438
  • [7] Schuster S, 1997, Z KARDIOL, V86, P273, DOI 10.1007/s003920050059
  • [8] Statins do not affect platelet inhibition with clopidogrel during coronary stenting
    Serebruany, VL
    Malinin, AI
    Callahan, KP
    Gurbel, PA
    Steinhubl, SR
    [J]. ATHEROSCLEROSIS, 2001, 159 (01) : 239 - 241
  • [9] Wagner S, 1999, Z KARDIOL, V88, P857, DOI 10.1007/s003920050362