Technology insight: noninvasive assessment of liver fibrosis by biochemical scores and elastography

被引：145

作者：

Pinzani, Massimo ^{[1
]}

Vizzutti, Francesco ^{[1
]}

Arena, Umberto ^{[1
]}

Marra, Fabio ^{[1
]}

机构：

[1] Univ Florence, Dipartimento Med Interna, I-50134 Florence, Italy

来源：

NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY | 2008年 / 5卷 / 02期

关键词：

fatty liver; liver fibrosis; noninvasive assessment; serum markers; transient elastography;

D O I：

10.1038/ncpgasthep1025

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Although histopathological analysis of liver tissue is still the reference standard for the evaluation of disease progression in patients with chronic liver disease, a distinct change in clinical practice is occurring. The tendency to substitute histopathological analysis of liver biopsies with complex, surrogate 'noninvasive' measures of disease progression has grown to such a level that clarification and guidance on their use is needed. This Review provides an overview of the proposed noninvasive diagnostic methodologies and their possible integration with the standard invasive procedures used for the evaluation of disease progression (i.e. liver biopsy and the measurement of portal pressure). A concise analysis of what has been proposed for the differentiation of simple fatty liver from nonalcoholic steatohepatitis and its possible fibrogenic evolution is also included. In particular, the Review focuses on the methods easily available as part of daily clinical practice in hepatology-biochemical markers and transient elastography (i.e. liver stiffness measurement).

引用

页码：95 / 106

页数：12

共 78 条

[1] The natural history of nonalcoholic fatty liver disease: A population-based cohort study [J].

Adams, LA ;

Lymp, JF ;

St Sauver, J ;

Sanderson, SO ;

Lindor, KD ;

Feldstein, A ;

Angulo, P .

GASTROENTEROLOGY, 2005, 129 (01) :113-121

[2] Hepascore: An accurate validated predictor of liver fibrosis in chronic hepatitis C infection [J].

Adams, LA ;

Bulsara, M ;

Rossi, E ;

Deboer, B ;

Speers, D ;

George, J ;

Kench, J ;

Farrell, G ;

McCaughan, GW ;

Jeffrey, GP .

CLINICAL CHEMISTRY, 2005, 51 (10) :1867-1873

[3] The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies [J].

Adams, LA ;

Sanderson, S ;

Lindor, KD ;

Angulo, P .

JOURNAL OF HEPATOLOGY, 2005, 42 (01) :132-138

[4] Technology evaluation: A critical step in the clinical utilization of novel diagnostic tests for liver fibrosis [J].

Afdhal, Nezam H. ;

Curry, Michael .

JOURNAL OF HEPATOLOGY, 2007, 46 (04) :543-545

[5] Immune response towards lipid peroxidation products as a predictor of progression of non-alcoholic fatty liver disease to advanced fibrosis [J].

Albano, E ;

Mottaran, E ;

Vidali, M ;

Reale, E ;

Saksena, S ;

Occhino, G ;

Burt, AD ;

Day, CP .

GUT, 2005, 54 (07) :987-993

[6] Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis [J].

Angulo, P ;

Keach, JC ;

Batts, KP ;

Lindor, KD .

HEPATOLOGY, 1999, 30 (06) :1356-1362

[7] Nonalcoholic fatty liver disease [J].

Brunt, Elizabeth M. ;

Wong, Vincent W. -S. ;

Nobili, Valerio ;

Day, Christopher P. ;

Sookoian, Silvia ;

Maher, Jacquelyn J. ;

Bugianesi, Elisabetta ;

Sirlin, Claude B. ;

Neuschwander-Tetri, BrentA. ;

Rinella, Mary E. .

NATURE REVIEWS DISEASE PRIMERS, 2015, 1

[8] The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD [J].

Angulo, Paul ;

Hui, Jason M. ;

Marchesini, Giulio ;

Bugianesi, Ellisabetta ;

George, Jacob ;

Farrell, Geoffrey C. ;

Enders, Felicity ;

Saksena, Sushma ;

Burt, Alastair D. ;

Bida, John P. ;

Lindor, Keith ;

Sanderson, Schuyler O. ;

Lenzi, Marco ;

Adams, Leon A. ;

Kench, James ;

Therneau, Terry M. ;

Day, Christopher P. .

HEPATOLOGY, 2007, 45 (04) :846-854

[9]

ARENA U, IN PRESS HEPATOLOGY

[10]

AZIZ MA, 2007, AM J GASTROENTEROL, V102, P1

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