Levels of lipoprotein and homocysteine in non-obese and obese patients with polylcystic ovary syndrome

被引:75
作者
Yilmaz, M
Biri, A
Bukan, N
Karakoç, A
Sancak, B
Törüner, F
Pasaoglu, H
机构
[1] Kirikkale Univ, Fac Med, Dept Endocrinol & Metab, Kirikkale, Turkey
[2] Gazi Univ, Fac Med, Dept Obstet & Gynecol, Ankara, Turkey
[3] Gazi Univ, Fac Med, Dept Biochem, Ankara, Turkey
[4] Gazi Univ, Fac Med, Dept Endocrinol & Metab, Ankara, Turkey
关键词
polycystic ovary syndrome; homocysteine; insulin resistance; cardiovascular disease; lipoprotein;
D O I
10.1080/09513590400027265
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aim. This study was designed to examine the relationship between homocysteine (Hcy), lipoprotein levels and insulin resistance in obese and non-obese patients with polycystic ovary syndrome (PCOS). Materials and methods. Eighty-five patients (38 obese, 47 non-obese) with PCOS and 50 healthy subjects (25 obese, 25 nonobese) were included in the study. PCOS was defined according to the Homburg criterion. Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEA-S), insulin, 17-hydroxyprogesterone, free testosterone, androstenedione, vitamin B-12 and folate were measured. Also, serum concentrations of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), lipoprotein (a) (Lp(a)), apoprotein B (Apo B) and apoprotein A (Apo A) were determined. Plasma Hey levels were measured. Insulin resistance was evaluated by homeostasis model assessment (HOMA). Results. Plasma Hey levels were significantly higher in women with PCOS than in healthy women. HOMA-R (insulin resistance) was significantly higher in women with PCOS compared with healthy women. Serum fasting TC, LDL-C, TG, Apo B, vitamin B-12 and folate levels were similar between PCOS and control groups. Lp(a) levels were higher in PCOS patients than in control subjects, whereas HDL-C and Apo A levels were lower. Compared with obese PCOS subjects, nonobese PCOS subjects had low HOMA-R, TC, LDL-C, TG, Apo B, Lp(a) and androgen levels. Plasma Hey levels, serum HDL-C and Apo A levels were similar between obese and non-obese women with PCOS. Levels of HDL-C and Apo A were lower in both obese and non-obese PCOS patients than in obese and non-obese control subjects, whereas Lp(a) levels were higher. No correlation was observed between Plasma Hey, body mass index, HOMA-R, serum androgen levels, TC, LDL-C, HDL-C, Apo A, Apo B and Lp(a) levels. Conclusion. These results showed that elevated insulin resistance and plasma Hey levels, and changes in serum lipid profile, which are possible risk factors for cardiovascular disorders, play important roles in the development of cardiovascular disease in both obese and non-obese patients with PCOS.
引用
收藏
页码:258 / 263
页数:6
相关论文
共 37 条
  • [1] AJABNOOR MA, 2003, MED SCI MONITOR, V9, P523
  • [2] Association between polycystic ovaries and extent of coronary artery disease in women having cardiac catheterization
    Birdsall, MA
    Farquhar, CM
    White, HD
    [J]. ANNALS OF INTERNAL MEDICINE, 1997, 126 (01) : 32 - 35
  • [3] Increased C-reactive protein levels in the polycystic ovary syndrome: A marker of cardiovascular disease
    Boulman, N
    Levy, Y
    Leiba, R
    Shachar, S
    Linn, R
    Zinder, O
    Blumenfeld, Z
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (05) : 2160 - 2165
  • [4] HOMOCYSTEINE AND CYSTEINE - DETERMINANTS OF PLASMA-LEVELS IN MIDDLE-AGED AND ELDERLY SUBJECTS
    BRATTSTROM, L
    LINDGREN, A
    ISRAELSSON, B
    ANDERSSON, A
    HULTBERG, B
    [J]. JOURNAL OF INTERNAL MEDICINE, 1994, 236 (06) : 633 - 641
  • [5] Buccianti G, 2004, J NEPHROL, V17, P405
  • [6] HYPERHOMOCYSTEINEMIA - AN INDEPENDENT RISK FACTOR FOR VASCULAR-DISEASE
    CLARKE, R
    DALY, L
    ROBINSON, K
    NAUGHTEN, E
    CAHALANE, S
    FOWLER, B
    GRAHAM, I
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (17) : 1149 - 1155
  • [7] Insulin-lowering agents in the management of polycystic ovary syndrome
    De Leo, V
    la Marca, A
    Petraglia, F
    [J]. ENDOCRINE REVIEWS, 2003, 24 (05) : 633 - 667
  • [8] De Pergola G, 2001, DIABETES NUTR METAB, V14, P253
  • [9] PROFOUND PERIPHERAL INSULIN RESISTANCE, INDEPENDENT OF OBESITY, IN POLYCYSTIC OVARY SYNDROME
    DUNAIF, A
    SEGAL, KR
    FUTTERWEIT, W
    DOBRJANSKY, A
    [J]. DIABETES, 1989, 38 (09) : 1165 - 1174
  • [10] Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis
    Dunaif, A
    [J]. ENDOCRINE REVIEWS, 1997, 18 (06) : 774 - 800