Palladium-catalyzed direct arylation of thiazoles with aryl bromides

被引：156

作者：

Yokooji, A ^{[1
]}

Okazawa, T ^{[1
]}

Satoh, T ^{[1
]}

Miura, M ^{[1
]}

Nomura, M ^{[1
]}

机构：

[1] Osaka Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan

来源：

TETRAHEDRON | 2003年 / 59卷 / 30期

关键词：

arylation; aryl halides; palladium and compounds; thiazoles;

D O I：

10.1016/S0040-4020(03)00879-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Thiazole, 2-phenyl or -alkyl substituted one and benzothiazole are efficiently arylated with aryl bromides at the 2- and/or 5-position(s) in the presence of Pd(OAc)(2) and a bulky phosphine ligand using Cs2Co3 as base. 2-Phenyl-5-thiazolecarboxanilide undergoes successive diarylation at the 4- and 5-positions accompanied by decarbamoylation. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：5685 / 5689

页数：5

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