Microinjection of morphine into the rostral ventromedial medulla produces greater antinociception in male compared to female rats

被引：99

作者：

Boyer, JS

Morgan, MM

Craft, RM

机构：

[1] Washington State Univ, Dept Psychol, Vancouver, WA 98686 USA

[2] Washington State Univ, Dept Psychol, Pullman, WA 99164 USA

来源：

BRAIN RESEARCH | 1998年 / 796卷 / 1-2期

关键词：

sex difference; pain modulation; analgesia; nucleus raphe magnus; locomotion; opioid;

D O I：

10.1016/S0006-8993(98)00353-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The antinociceptive and locomotor effects of microinjecting morphine into the rostral ventromedial medulla (RVM) of male and female rats was assessed. Male rats showed greater antinociception than female rats at all doses and times following morphine administration. Male, but not female rats, also showed a dose dependent decrease in locomotion. These data demonstrate that sex differences in antinociception are mediated at least in part by the RVM. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：315 / 318

页数：4

共 31 条

[1] ANALGESIA INDUCED BY MICRO-INJECTION OF MORPHINE INTO, AND ELECTRICAL-STIMULATION OF, NUCLEUS RETICULARIS PARAGIGANTOCELLULARIS OF RAT MEDULLA-OBLONGATA [J].