Ligand- and substrate-based 19F NMR screening:: Principles and applications to drug discovery

被引：157

作者：

Dalvit, Claudio ^{[1
]}

机构：

[1] Nerviano Med Sci, Dept Chem, I-20014 Nerviano, MI, Italy

来源：

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY | 2007年 / 51卷 / 04期

关键词：

fluorine NMR-based screening; fragment-based screening; competition binding experiments; enzyme inhibition; drug discovery;

D O I：

10.1016/j.pnmrs.2007.07.002

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

[No abstract available]

引用

页码：243 / I

页数：29

共 198 条

[1] Ligand efficiency indices as guideposts for drug discovery [J].

Abad-Zapatero, C ;

Metz, JT .

DRUG DISCOVERY TODAY, 2005, 10 (07) :464-469

[2]

ABADZAPATERO C, 2006, FRAGMENT BASED APPRO, P249

[3] Concentration measurement by proton NMR using the ERETIC method [J].

Akoka, S ;

Barantin, L ;

Trierweiler, M .

ANALYTICAL CHEMISTRY, 1999, 71 (13) :2554-2557

[4] SPIN-ECHO NMR STUDIES OF CHEMICAL EXCHANGE .1. SOME GENERAL ASPECTS [J].

ALLERHAND, A ;

GUTOWSKY, HS .

JOURNAL OF CHEMICAL PHYSICS, 1964, 41 (07) :2115-&

[5] In situ 19F NMR spectroscopy study of enzymatic transglycosylation reactions using α-D-aldohexopyranosyl fluorides as donors and accepters [J].

André, C ;

Spangenberg, P ;

Gentil, E ;

Rabiller, C .

TETRAHEDRON-ASYMMETRY, 2001, 12 (05) :779-783

[6]

[Anonymous], 1985, Enzyme Structure and Mechanism

[7]

AUSMAN DJ, 2001, MODERN DRUG DISCOVER, V4, P33

[8] A new method for absolute quantitation of MRS metabolites [J].

Barantin, L ;

LePape, A ;

Akoka, S .

MAGNETIC RESONANCE IN MEDICINE, 1997, 38 (02) :179-182

[9] Fragment screening by biochemical assay [J].

Barker, John ;

Courtney, Steve ;

Hesterkamp, Thomas ;

Ullmann, Dirk ;

Whittaker, Mark .

EXPERT OPINION ON DRUG DISCOVERY, 2006, 1 (03) :225-236

[10]

Bartoli S., 2006, DRUG DISCOV TODAY TE, V3, P425, DOI DOI 10.1016/J.DDTEC.2006.12.001

← 1 2 3 4 5 6 7 8 9 10 →