β-ketoacyl acyl carrier protein synthase III (FabH) is essential for fatty acid biosynthesis in Streptomyces coelicolor A3(2)

被引:67
作者
Revill, WP [1 ]
Bibb, MJ [1 ]
Scheu, AK [1 ]
Kieser, HJ [1 ]
Hopwood, DA [1 ]
机构
[1] John Innes Ctr Plant Sci Res, Norwich NR4 7UH, Norfolk, England
关键词
D O I
10.1128/JB.183.11.3526-3530.2001
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The Streptomyces coelicolor fab (fatty acid biosynthesis) gene cluster (fabD-fabH-acpP-fabF) is cotranscribed to produce a leaderless mRNA transcript. One of these genes, fabH, encodes a ketoacyl synthase III that is essential to and is proposed to be responsible for initiation of fatty acid biosynthesis in S. coelicolor.
引用
收藏
页码:3526 / 3530
页数:5
相关论文
共 20 条
[1]   PLASMID CLONING VECTORS FOR THE CONJUGAL TRANSFER OF DNA FROM ESCHERICHIA-COLI TO STREPTOMYCES SPP [J].
BIERMAN, M ;
LOGAN, R ;
OBRIEN, K ;
SENO, ET ;
RAO, RN ;
SCHONER, BE .
GENE, 1992, 116 (01) :43-49
[2]   β-ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis [J].
Choi, KH ;
Heath, RJ ;
Rock, CO .
JOURNAL OF BACTERIOLOGY, 2000, 182 (02) :365-370
[3]   POLYKETIDE SYNTHASE ACYL CARRIER PROTEINS FROM STREPTOMYCES - EXPRESSION IN ESCHERICHIA-COLI, PURIFICATION AND PARTIAL CHARACTERIZATION [J].
CROSBY, J ;
SHERMAN, DH ;
BIBB, MJ ;
REVILL, WP ;
HOPWOOD, DA ;
SIMPSON, TJ .
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1995, 1251 (01) :32-42
[4]  
ENGLARD S, 1990, METHOD ENZYMOL, V182, P285
[5]  
FLATMAN S, 1983, BIOCHEM SOC T, V11, P597
[6]  
Flett F, 1997, FEMS MICROBIOL LETT, V155, P223, DOI 10.1016/S0378-1097(97)00392-3
[7]   ACETOACYL-ACYL CARRIER PROTEIN SYNTHASE FROM AVOCADO - ITS PURIFICATION, CHARACTERIZATION AND CLEAR RESOLUTION FROM ACETYL COA-ACP TRANSACYLASE [J].
GULLIVER, BS ;
SLABAS, AR .
PLANT MOLECULAR BIOLOGY, 1994, 25 (02) :179-191
[8]   Characterization of β-ketoacyl-acyl carrier protein synthase III from Streptomyces glaucescens and its role in initiation of fatty acid biosynthesis [J].
Han, L ;
Lobo, S ;
Reynolds, KA .
JOURNAL OF BACTERIOLOGY, 1998, 180 (17) :4481-4486
[9]   ENOYL-ACYL CARRIER PROTEIN REDUCTASE (FABI) PLAYS A DETERMINANT ROLE IN COMPLETING CYCLES OF FATTY-ACID ELONGATION IN ESCHERICHIA-COLI [J].
HEATH, RJ ;
ROCK, CO .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (44) :26538-26542
[10]  
JANSSEN GR, 1993, INDUSTRIAL MICROORGANISMS: BASIC AND APPLIED MOLECULAR GENETICS, P59