Evidence for Viral Induction of Biliary Atresia: A Review

被引:40
作者
Averbukh, Leon D. [1 ]
Wu, George Y. [1 ]
机构
[1] Univ Connecticut, Dept Med, Div Gastroenterol Hepatol, Hlth Ctr, 236 Farmington Ave, Farmington, CT 06030 USA
关键词
Biliary atresia; Cytomegalovirus; Epstein-Barr virus; Reovirus; Rotavirus; EPSTEIN-BARR-VIRUS; POLYMERASE-CHAIN-REACTION; BILE-DUCT ATRESIA; CYTOMEGALOVIRUS-INFECTION; BREAST-MILK; PERINATAL INFECTION; SEQUENCE DIVERSITY; EPITHELIAL-CELLS; C ROTAVIRUS; INFANTS;
D O I
10.14218/JCTH.2018.00046
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
Biliary atresia (BA) is a childhood disease which manifests with abnormal narrowing, blockage or complete absence of bile ducts within the liver. Many possible etiologies have been reported for the development of BA, including congenital, perinatal and acquired conditions. Since the 1970's, there has been increasing evidence linking BA development to viral perinatal infections. The viral vectors most commonly implicated include members of the herpesviridae family (cytomegalovirus and Epstein-Barr virus) as well as those of the reoviridae family (reovirus and rotavirus). While extensive work has been done on a murine model of disease, the current review focuses primarily on evidence from human studies of viral vectors in children afflicted with BA.
引用
收藏
页码:410 / 419
页数:10
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