Stereoselective synthesis of the bicyclo[5.3.0]decane portion of the diterpene antibiotic guanacastepene using a pyrylium-ylide [5+2] cycloaddition reaction

被引：52

作者：

Magnus, P ^{[1
]}

Waring, MJ ^{[1
]}

Ollivier, C ^{[1
]}

Lynch, V ^{[1
]}

机构：

[1] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 30期

关键词：

guanacastepene; antibiotic; pyrylium-ylide; conjugate addition;

D O I：

10.1016/S0040-4039(01)00851-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of 14 with Ac2O/Et3N resulted in [5+2] cyclization to give 2, which was further elaborated into 20, thus establishing the required stereochemistry in the top-half of guanacastepene 1. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：4947 / 4950

页数：4

共 20 条

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