Human immunodeficiency virus strains differ in their ability to infect CD4(+) cells expressing the rat homolog of CXCR-4 (fusin)

被引：61

作者：

Pleskoff, O ^{[1
]}

Sol, N ^{[1
]}

Labrosse, B ^{[1
]}

Alizon, M ^{[1
]}

机构：

[1] INST COCHIN GENET MOL,INSERM,U332,F-75014 PARIS,FRANCE

来源：

JOURNAL OF VIROLOGY | 1997年 / 71卷 / 04期

关键词：

D O I：

10.1128/JVI.71.4.3259-3262.1997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A clade B strain of human immunodeficiency virus type 1 (HIV-1(LAI)) could infect CD4(+) cells expressing human CXCR-4 (fusin) or its rat homolog with similar efficacy. By contrast, cells expressing rat CXCR-4 were not permissive to HIV1(NDK) (clade D), HIV-2(ROD), or HIV-1(LAI) with chimeric envelope protein gp120 bearing the V3 domain from HIV-1(NDK). The reciprocal chimeric gp120 (HIV-1(NDK) with V3 from HIV-1(LAI)) could mediate infection of cells expressing either human or rat CXCR-4. Genetically divergent HIV strains have different requirements for interaction with the CXCR-4 coreceptor, and the gp120 V3 domain seems to be involved in this interaction.

引用

页码：3259 / 3262

页数：4

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