Phenolic constituents from Ephedra nebrodensis

被引：46

作者：

Cottiglia, F

Bonsignore, L

Casu, L

Deidda, D

Pompei, R

Casu, M

Floris, C

机构：

[1] Univ Cagliari, Fac Pharm, Dipartimento Farmaco Chim Tecnol, I-09124 Cagliari, Italy

[2] Univ Cagliari, Cattedra Microbiol Applicata, I-09124 Cagliari, Italy

[3] Univ Cagliari, Dipartimento Sci Chim, I-09042 Monserrato, Italy

来源：

NATURAL PRODUCT RESEARCH | 2005年 / 19卷 / 02期

关键词：

Ephedra nebrodensis; Ephedraceae; phenolic glycosides; anti-influenza A virus activity; MDCK cells;

D O I：

10.1080/14786410410001704714

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new phenolic glycosides, 4-hydroxy-3-(3-methyl-2-butenyl)phenyl beta-D-glucopyranoside (nebrodenside A) and O-coumaric acid beta-D-allopyranoside (nebrodenside B), were isolated from the aerial parts of Ephedra nebrodensis. In addition, O-coumaric acid glucoside, (-)-epicatechin, and (-)-ephedrine were also isolated. The structures were deduced from extensive 1D and 2D NMR spectroscopy (H-1, C-13, DQF-COSY, TOCSY, GHSQC, GHMQC, ROESY) as well as mass spectrometry (E1 and HR-MALDI). (-)-Epicatechin showed weak antiviral activity against Influenza A virus and very weak cytotoxicity against MDCK cells.

引用

页码：117 / 123

页数：7

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