Design, synthesis and antiproliferative activity of novel aminosubstituted benzothiopyranoisoindoles

被引：10

作者：

Christodoulou, Antonios ^{[1
]}

Kostakis, Ioannis K. ^{[1
]}

Kourafalos, Vassilios ^{[1
]}

Pouli, Nicole ^{[1
]}

Marakos, Panagiotis ^{[1
]}

Trougakos, Ioannis P. ^{[2
]}

Tsitsilonis, Ourania E. ^{[3
]}

机构：

[1] Univ Athens, Dept Pharm, Div Pharmaceut Chem, GR-15771 Athens, Greece

[2] Univ Athens, Dept Cell Biol & Biophys, Fac Biol, Athens 15784, Greece

[3] Univ Athens, Fac Biol, Dept Anim & Human Physiol, Athens 15784, Greece

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 10期

关键词：

Thioxanthone analogues; Fuzed isoindoles; Nitracrine; Cytotoxic activity; Multi-drug resistance; BREAST-CANCER CELLS; ANTI-TUMOR; 1-NITROACRIDINES; GROWTH-INHIBITORY-ACTIVITY; SELECTIVE TOXICITY; BACTERIAL-CELLS; SIDE-CHAIN; NITRACRINE; RING; DERIVATIVES; LEDAKRIN;

D O I：

10.1016/j.bmcl.2011.03.021

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The synthesis of a number of new benzothiopyrano[4,3,2-cd] isoindole aminoderivatives designed as structural analogues of the key metabolite of the anticancer agent Ledacrine ( nitracrine) and their in vitro cytotoxic activity evaluation against HCT-116, MES-SA, and MES-SA/Dx cancer cell lines is reported. The majority of the derivatives possessed noticeable cytotoxicity in a low mu M range indicating an interesting structure-activity relationship. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：3110 / 3112

页数：3

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