Obesity -: Aquaporin enters the picture

被引：96

作者：

Frühbeck, G ^{[1
]}

机构：

[1] Univ Navarra, Clin Univ, Dept Endocrinol, Pamplona 31008, Spain

来源：

NATURE | 2005年 / 438卷 / 7067期

关键词：

D O I：

10.1038/438436b

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The aquaporins are membrane channels that were originally identified as regulators of a cell's water balance. A member of the aquaporin family is now implicated as a central agent in controlling fat metabolism.

引用

页码：436 / 437

页数：2

共 9 条

[1] Progressive adipocyte hypertrophy in aquaporin-7-deficient mice - Adipocyte glycerol permeability as a novel regulator of fat accumulation [J].

Hara-Chikuma, M ;

Sohara, E ;

Rai, T ;

Ikawa, M ;

Okabe, M ;

Sasaki, S ;

Uchida, S ;

Verkman, AS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (16) :15493-15496

[2] Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase [J].

Hibuse, T ;

Maeda, N ;

Funahashi, T ;

Yamamoto, K ;

Nagasawa, A ;

Mizunoya, W ;

Kishida, K ;

Inoue, K ;

Kuriyama, H ;

Nakamura, T ;

Fushiki, T ;

Kihara, S ;

Shimomura, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (31) :10993-10998

[3] From structure to disease: The evolving tale of aquaporin biology [J].

King, LS ;

Kozono, D ;

Agre, P .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (09) :687-698

[4] Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel [J].

Kishida, K ;

Shimomura, I ;

Kondo, H ;

Kuriyama, H ;

Makino, Y ;

Nishizawa, H ;

Maeda, N ;

Matsuda, M ;

Ouchi, N ;

Kihara, S ;

Kurachi, Y ;

Funahashi, T ;

Matsuzawa, Y .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (39) :36251-36260

[5] Human aquaporin adipose (AQPap) gene - Genomic structure, promoter analysis and functional mutation [J].

Kondo, H ;

Shimomura, I ;

Kishida, K ;

Kuriyama, H ;

Makino, Y ;

Nishizawa, H ;

Matsuda, M ;

Maeda, N ;

Nagaretani, H ;

Kihara, S ;

Kurachi, Y ;

Nakamura, T ;

Funahashi, T ;

Matsuzawa, Y .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2002, 269 (07) :1814-1826

[6] Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9 [J].

Kuriyama, H ;

Shimomura, I ;

Kishida, K ;

Kondo, H ;

Furuyama, N ;

Nishizawa, H ;

Maeda, N ;

Matsuda, M ;

Nagaretani, H ;

Kihara, S ;

Nakamura, T ;

Tochino, Y ;

Funahashi, T ;

Matsuzawa, Y .

DIABETES, 2002, 51 (10) :2915-2921

[7] Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability [J].

Kuriyama, H ;

Kawamoto, S ;

Ishida, N ;

Ohno, I ;

Mita, S ;

Matsuzawa, Y ;

Matsubara, K ;

Okubo, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 241 (01) :53-58

[8] Obesity and metabolic perturbations after loss of aquaporin 7, the adipose glycerol transporter [J].

MacDougald, OA ;

Burant, CF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (31) :10759-10760

[9] Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue [J].

Maeda, N ;

Funahashi, T ;

Hibuse, T ;

Nagasawa, A ;

Kishida, K ;

Kuriyama, H ;

Nakamura, T ;

Kihara, S ;

Shimomura, I ;

Matsuzawa, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (51) :17801-17806

← 1 →