Autocrine PDGF stimulation in malignancies

被引：73

作者：

Heldin, Carl-Henrik ^{[1
]}

机构：

[1] Uppsala Univ, Ludwig Inst Canc Res, BMC, S-75124 Uppsala, Sweden

来源：

UPSALA JOURNAL OF MEDICAL SCIENCES | 2012年 / 117卷 / 02期

关键词：

Molecular biology; oncogenes; tumor biology; GROWTH-FACTOR-RECEPTOR; SIMIAN SARCOMA-VIRUS; PROSTATE-CANCER CELLS; CHRONIC MYELOMONOCYTIC LEUKEMIA; IDIOPATHIC HYPEREOSINOPHILIC SYNDROME; COMPARATIVE GENOMIC HYBRIDIZATION; SIGNAL-TRANSDUCTION PATHWAYS; SIS-TRANSFORMED-CELLS; FACTOR-BETA RECEPTOR; FACTOR-B;

D O I：

10.3109/03009734.2012.658119

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Platelet-derived growth factor (PDGF) isoforms are important mitogens for different types of mesenchymal cells, which have important functions during the embryonal development and in the adult during wound healing and tissue homeostasis. In tumors, PDGF isoforms are often over-expressed and contribute to the growth of both normal and malignant cells. This review focuses on tumors expressing PDGF isoforms together with their tyrosine kinase receptors, thus resulting in autocrine stimulation of growth and survival. Patients with such tumors could benefit from treatment with inhibitors of either PDGF or PDGF receptors.

引用

页码：83 / 91

页数：9

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