Protein oxidation and ageing

被引:84
作者
Linton, S
Davies, MJ
Dean, RT
机构
[1] Heart Res Inst, Cell Biol Grp, Sydney, NSW 2050, Australia
[2] Heart Res Inst, EPR Grp, Sydney, NSW 2050, Australia
基金
澳大利亚研究理事会; 英国惠康基金; 英国医学研究理事会;
关键词
protein oxidation; radicals; oxidative stress; reactive oxygen species; ageing;
D O I
10.1016/S0531-5565(01)00136-X
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Organisms produce reactive oxygen species (ROS) throughout their lives. The activities of a number of key antioxidant enzymes, such as catalase, superoxide dismutase and glutathione peroxidase, which protect against the damaging effects of ROS, have been reported to decrease with increasing age, though this is not unequivocal. In contrast, sacrificial antioxidants such as ascorbate, thiols and tocopherol do not appear to decrease with increasing age. It is also possible that ROS production increases with age as a result of poorer coupling of electron transport components, and an increased level of redox-active metal ions that could catalyse oxidant formation. As a result of this decrease in antioxidant defences, and increased rate of ROS formation, it is possible that the impact of ROS increases with age. ROS are known to oxidise biological macromolecules, with proteins an important target. If the argument that the impact of ROS increases with age is true, then proteins would be expected to accumulate oxidised materials with age, and the rate of such accumulation should increase with time, reflecting impaired inefficiency of homeostasis. Here we review the evidence for the accumulation of oxidised, or modified, extra- and intra-cellular proteins in vivo. (C) 2001 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:1503 / 1518
页数:16
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