Pd-catalyzed asymmetric allylic alkylation of 2-substituted cycloalkenyl carbonates using a chiral diaminophosphine oxide:: (S,RP)-Ph-DIAPHOX

被引：13

作者：

Jin, Long ^{[1
]}

Nemoto, Tetsuhiro ^{[1
]}

Nakamura, Hiroshi ^{[1
]}

Hamada, Yasumasa ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2008年 / 19卷 / 09期

关键词：

D O I：

10.1016/j.tetasy.2008.03.027

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A Pd-catalyzed asymmetric allylic alkylation of 2-substituted cycloalkenyl carbonates using a chiral diaminophosphine oxide is described. Asymmetric allylic substitution of various cyclic substrates proceeded using 5 mol % of Pd catalyst, 10 mol % of (S,RP)-Ph-DIAPHOX 1, 10 mol % of LiOAc, and N,O-bis(trimethylsilyl)acetamide (BSA), to afford the corresponding products in excellent yields with up to 92% ee. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1106 / 1113

页数：8

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