Death by influenza virus protein

被引:45
作者
Lamb, RA [1 ]
Takeda, M
机构
[1] Howard Hughes Med Inst, Evanston, IL USA
[2] Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL USA
关键词
D O I
10.1038/nm1201-1286
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The identification of a new influenza virus protein PB1-F2, which localizes to mitochondria and causes cell death, may offer important insights into pathogenicity, as well as providing another example of how the virus can expand the coding capacity of its genome using overlapping reading frames.
引用
收藏
页码:1286 / 1288
页数:3
相关论文
共 12 条
[1]  
[Anonymous], 2001, FUNDAMENTAL VIROLOGY
[2]   A novel influenza A virus mitochondrial protein that induces cell death [J].
Chen, WS ;
Calvo, PA ;
Malide, D ;
Gibbs, J ;
Schubert, U ;
Bacik, I ;
Basta, S ;
O'Neill, R ;
Schickli, J ;
Palese, P ;
Henklein, P ;
Bennink, JR ;
Yewdell, JW .
NATURE MEDICINE, 2001, 7 (12) :1306-1312
[3]   Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA viruses [J].
García-Sastre, A .
VIROLOGY, 2001, 279 (02) :375-384
[4]   Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses [J].
Hatta, M ;
Gao, P ;
Halfmann, P ;
Kawaoka, Y .
SCIENCE, 2001, 293 (5536) :1840-1842
[5]  
Lamb R., 1983, Genetics of influenza viruses, P26
[6]  
Lamb R.A., 2001, Fields's Virology, P1487
[7]  
Lamb R.A., 2001, Fields virology, P1305
[8]   Influenza B and C virus NEP (NS2) proteins possess nuclear export activities [J].
Paragas, J ;
Talon, J ;
O'Neill, RE ;
Anderson, DK ;
García-Sastre, A ;
Palese, P .
JOURNAL OF VIROLOGY, 2001, 75 (16) :7375-7383
[9]   Influenza virus NS1 protein induces apoptosis in cultured cells [J].
Schultz-Cherry, S ;
Dybdahl-Sissoko, N ;
Neumann, G ;
Kawaoka, Y ;
Hinshaw, VS .
JOURNAL OF VIROLOGY, 2001, 75 (17) :7875-7881
[10]   Role of hemagglutinin cleavage for the pathogenicity of influenza virus [J].
Steinhauer, DA .
VIROLOGY, 1999, 258 (01) :1-20