Novel prenyltransferase enzymes as a tool for flavonoid prenylation

被引：90

作者：

Botta, B ^{[1
]}

Delle Monache, G

Menendez, P

Boffi, A

机构：

[1] Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biologi, I-00185 Rome, Italy

[2] Fac Quim Montevideo, Catedra Farmacognos & Prod Nat, Montevideo, Uruguay

[3] Univ Roma La Sapienza, Dipartimento Sci Biochim, I-00185 Rome, Italy

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2005年 / 26卷 / 12期

关键词：

D O I：

10.1016/j.tips.2005.09.012

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The recent identification of genes encoding a novel family of soluble aromatic prenyltransferases from Streptomyces species and the structural characterization of one of these proteins are challenging discoveries in the biochemistry of natural compounds. In addition to their notable physiological role in the biosynthesis of aminocoumarin antibiotics, these enzymes represent an advanced tool for exploring novel isoprenoid substitutions in aromatic compounds and are expected to foster the emerging pharmacological applications of prenylated flavonoids.

引用

页码：606 / 608

页数：3

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