Regulation of tumour necrosis factor signalling: live or let die

被引：916

作者：

Brenner, Dirk ^{[1
]}

Blaser, Heiko ^{[2
]}

Mak, Tak W. ^{[2
,3
,4
]}

机构：

[1] Luxembourg Inst Hlth, Dept Infect & Immun Expt & Mol Immunol, L-4354 Esch Sur Alzette, Luxembourg

[2] Univ Hlth Network, Ontario Canc Inst, Campbell Family Canc Res Inst, Toronto, ON M5G 2M9, Canada

[3] Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada

[4] Univ Toronto, Fac Med, Dept Med Biophys, Toronto, ON M5G 1L7, Canada

来源：

NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 06期

关键词：

NF-KAPPA-B; MIXED LINEAGE KINASE; INDUCED CELL-DEATH; DOMAIN-LIKE PROTEIN; RANDOMIZED CONTROLLED-TRIALS; ALPHA-DEPENDENT APOPTOSIS; CHAIN ASSEMBLY COMPLEX; TOLL-LIKE-RECEPTORS; ANTI-TNF THERAPY; RHEUMATOID-ARTHRITIS;

D O I：

10.1038/nri3834

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that has important roles in mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) signalling is associated with many inflammatory disorders, including various types of arthritis and inflammatory bowel disease, and targeting TNF has been an effective therapeutic strategy in these diseases. This Review focuses on the recent advances that have been made in understanding TNFR signalling and the consequences of its deregulation for cellular survival, apoptosis and regulated necrosis. We discuss how TNF-induced survival signals are distinguished from those that lead to cell death. Finally, we provide a brief overview of the role of TNF in inflammatory and autoimmune diseases, and we discuss up-to-date and future treatment strategies for these disorders.

引用

收藏

页码：362 / 374

页数：13

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