Polyclonal antibody-induced serum sickness in renal transplant recipients: treatment with therapeutic plasma exchange

被引：41

作者：

Tanriover, B

Chuang, P

Fishbach, B

Helderman, JH

Kizilisik, T

Nylander, W

Shaffer, D

Langone, AJ

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Med, Div Nephrol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Med Ctr, Dept Surg, Div Rena Transplant Surg, Nashville, TN 37232 USA

来源：

TRANSPLANTATION | 2005年 / 80卷 / 02期

关键词：

D O I：

10.1097/01.TP.0000165093.13046.B3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Serum sickness is an immune-complex mediated illness that frequently occurs in patients after polyclonal antibody therapy (ATGAM or thymoglobulin). Serum sickness presents with significant morbidity but is self-limited and resolves with prolonged steroid therapy. We present five renal transplant patients who developed serum sickness after polyclonal antibody treatment with severe symptoms that persisted after being started on systemic steroids. These patients underwent one or two courses of therapeutic plasma exchange (TPE) with subsequent complete resolution of their symptoms. Renal transplant recipients with serum sickness after polyclonal antibody therapy may benefit from TPE by accelerating their time to recovery and thereby reducing overall morbidity.

引用

收藏

页码：279 / 281

页数：3

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