Gastrodin reduces IL-1β-induced apoptosis, inflammation, and matrix catabolism in osteoarthritis chondrocytes and attenuates rat cartilage degeneration in vivo

被引：62

作者：

Chen, Jian ^{[1
,2
]}

Gu, Yun-Tao ^{[1
,2
]}

Xie, Jun-Jun ^{[3
]}

Wu, Cong-Cong ^{[1
,2
]}

Xuan, Jun ^{[1
,2
]}

Guo, Wei-Jun ^{[1
,2
]}

Yan, Ying-Zhao ^{[1
,2
]}

Chen, Long ^{[1
,2
]}

Wu, Yao-Sen ^{[1
,2
]}

Zhang, Xiao-Lei ^{[1
,2
]}

Xiao, Jian ^{[3
]}

Wang, Xiang-Yang ^{[1
,2
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed Surg, Wenzhou 325027, Peoples R China

[2] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Peoples R China

[3] Wenzhou Med Univ, Sch Pharmaceut Sci, Key Lab Biotechnol & Pharmaceut Engn, Wenzhou 325027, Zhejiang, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 97卷

关键词：

Gastrodin; NF-kappa B; Inflammation; Apoptosis; Osteoarthritis; NF-KAPPA-B; STRESS-INDUCED APOPTOSIS; ARTICULAR-CARTILAGE; OXIDATIVE STRESS; INHIBITION; METABOLISM; MEDIATORS; DISEASE; METALLOPROTEINASE; OSTEOPOROSIS;

D O I：

10.1016/j.biopha.2017.10.067

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Therapeutics for osteoarthritis (OA) are intended to restore chondrocyte function and inhibit cell apoptosis. Previous studies have shown that gastrodin had anti-apoptotic and anti-inflammatory effects. However, little is known about whether gastrodin has protective effects against the processes of OA. We studied the potential effects of gastrodin on chondrocytes and the underlying mechanisms. Our results showed that gastrodin could prevent chondrocyte apoptosis induced by IL-1 beta. Additionally, gastrodin suppressed the nuclear factor kappa B (NF-kappa B) pathway, decreased the release of inflammatory mediators (IL-6, TNF-alpha), and reduced matrix catabolism in IL-1 beta-treated chondrocytes. Furthermore, gastrodin ameliorated rat cartilage degeneration in an OA model of knee joints in vivo, suggesting its potential as a candidate therapeutic for OA.

引用

页码：642 / 651

页数：10

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