Targeting and retention of magnetic targeted carriers (MTCs) enhancing intra-arterial chemotherapy

被引：214

作者：

Goodwin, S

Peterson, C

Hoh, C

Bittner, C

机构：

[1] Univ Calif Los Angeles, Dept Radiol, Med Ctr, Los Angeles, CA 90095 USA

[2] FeRx Inc, San Diego, CA 90095 USA

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 1999年 / 194卷 / 1-3期

关键词：

regional drug delivery; magnetic targeting; microparticle; chemotherapeutic drugs;

D O I：

10.1016/S0304-8853(98)00584-8

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

MTCs were magnetically targeted and retained at a region of interest in a swine model after intra-arterial infusion. MTCs did not redistribute after removal of the magnetic field. Histopathology results demonstrated high particle density in the area of the magnetic field. Particles were observed in the interstitium and occasionally intra-arterially. Regional delivery of chemotherapeutic drugs will be tested with this technology. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：132 / 139

页数：8

共 5 条

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