Bacterial nitric oxide synthesis

被引:78
作者
Cutruzzolà, F [1 ]
机构
[1] Univ Rome La Sapienza, Dipartimento Sci Biochim, I-00185 Rome, Italy
来源
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 1999年 / 1411卷 / 2-3期
关键词
denitrification; nitrite reductase; cytochrome cd(1); copper; nitric oxide dependent gene regulation;
D O I
10.1016/S0005-2728(99)00017-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The structure-function relationships in nitrite reductases, key enzymes in the dissimilatory denitrification pathway which reduce nitrite to nitric oxide (NO), are reviewed in this paper. The mechanisms of NO production are discussed in detail and special attention is paid to new structural information, such as the high resolution structure of the copper- and heme-containing enzymes from different sources. Finally, some implications relevant to regulation of the steady state levels of NO in denitrifiers are presented. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:231 / 249
页数:19
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