Enhanced oral exposure of diltiazem by the concomitant use of naringin in rats

The present study aims to investigate the effect of naringin, a flavonoid, on the pharmacokinetics of diltiazem and its active metabolite, desacetyldiltiazem, in rats. Pharmacokinetic parameters of diltiazem and desacetyldiltiazem were determined in rats following an oral administration of diltiazem (15 mg kg(-1)) to rats in the presence and absence of naringin (5 and 15 mg kg(-1)). Compared to the control given diltiazem alone, the C-max and AUC of diltiazem increased by twofolds in rats pretreated with naringin, while there was no significant change in T-max and terminal plasma half-life (T-1/2) of diltiazem. Consequently, absolute and relative bioavailability values of diltiazem in the presence of naringin were significantly higher (p < 0.05) than those from the control group. Metabolite-parent AUC ratio in the presence of naringin decreased by 30% compared to the control group, implying that naringin could be effective to inhibit the metabolism of diltiazem. In conclusion, the concomitant use of naringin significantly enhanced the oral exposure of diltiazem in rats. (c) 2005 Elsevier B.V. All rights reserved.