Monoclonal antibody-based therapy of neuroblastoma

被引：32

作者：

Cheung, NKV ^{[1
]}

Kushner, BH ^{[1
]}

Kramer, K ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Pediat, New York, NY 10021 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2001年 / 15卷 / 05期

关键词：

D O I：

10.1016/S0889-8588(05)70255-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Metastatic solid tumors in children are difficult to cure. Despite intensive chemoradiotherapy plus aggressive surgery, eradicating these diseases has remained a formidable challenge. Differentiation therapy and monoclonal antibody (mAb) may improve the outlook of patients with stage 4 neuroblastoma, The idiotype network appears to represent one component of a complex mechanism for success with mAb immunotherapy. Ongoing strategies to genetically re-engineer mAbs may offer now treatment possibilities against some of these deadly cancers in pediatrics.

引用

页码：853 / +

页数：15

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