Palladium catalyzed activation of borane-amine adducts:: rate enhancement of amine-borane methanolysis in the reduction of nitrobenzenes to anilines

被引：23

作者：

Couturier, M ^{[1
]}

Tucker, JL ^{[1
]}

Andresen, BM ^{[1
]}

Dubé, E ^{[1
]}

Brenek, SJ ^{[1
]}

Negri, JT ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Chem Res & Dev, Groton, CT 06340 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 12期

关键词：

D O I：

10.1016/S0040-4039(01)00166-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hydrolytically stable borane-amines can be activated in situ through palladium catalysis and perform reductions not possible otherwise. Hence, borane-trimethylamine is an efficient hydrogen-transfer reagent for the open vessel reduction of nitroaryls to anilines. Likewise, the palladium catalyzed methanolysis/decomplexation of stable borane-amine adducts is accelerated by the action of nitrobenzene. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2285 / 2288

页数：4

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