Resveratrol and derivatives for the prevention and treatment of cancer

被引：208

作者：

Fulda, Simone ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany

来源：

DRUG DISCOVERY TODAY | 2010年 / 15卷 / 17-18期

关键词：

CELL-CYCLE ARREST; PROMYELOCYTIC LEUKEMIA-CELLS; CHEMOPREVENTIVE AGENT RESVERATROL; APOPTOSIS-INDUCING AGENTS; COLON-CANCER; CARCINOMA CELLS; ANTIOXIDANT ACTIVITY; DOWN-REGULATION; RIBONUCLEOTIDE REDUCTASE; SUPEROXIDE-DISMUTASE;

D O I：

10.1016/j.drudis.2010.07.005

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Resveratrol, a naturally derived stilbene that exists in various foods and beverages, has attracted increasing attention over the past decade because of its multiple beneficial properties, including chemopreventive and antitumor activities. There are several other natural derivatives of resveratrol that are structurally similar to resveratrol and are also present in food. In addition, a series of resveratrol analogs have been synthesized by the addition of defined functional groups to increase the potency and/or enhance the activity of specific properties of resveratrol. Such resveratrol derivatives might provide promising tools as cancer chemopreventive agents, as well as cancer therapeutics in the prevention and treatment of cancer. This review provides an overview of key derivatives of resveratrol as cancer therapeutics.

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页码：757 / 765

页数：9

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