Remodelling at the maternal-fetal interface: relevance to human pregnancy disorders

被引:247
作者
Cartwright, Judith E. [1 ]
Fraser, Rupsha [1 ]
Leslie, Karin [1 ]
Wallace, Alison E. [1 ]
James, Joanna L. [1 ]
机构
[1] Univ London, Div Basic Med Sci, London SW17 0RE, England
关键词
UTERINE ARTERY DOPPLER; LEUKEMIA INHIBITORY FACTOR; NATURAL-KILLER-CELLS; DECIDUAL NK CELLS; ENDOVASCULAR TROPHOBLAST INVASION; ACTIVATED PROTEIN-KINASE; PLACENTAL BED; IN-VITRO; HUMAN ENDOMETRIUM; SPIRAL ARTERIES;
D O I
10.1530/REP-10-0294
中图分类号
Q [生物科学];
学科分类号
090105 [作物生产系统与生态工程];
摘要
In human pregnancy, successful placentation and remodelling of the uterine vasculature require the integration of a number of stages, which are crucial for a healthy pregnancy. As the demands of the developing fetus for nutrients and oxygen increase, the capacity of the maternal blood vessels to supply this must be altered radically, with deficiencies in this process implicated in a number of dangerous pregnancy complications. The complex signalling networks that regulate these tightly co-ordinated events are becoming clearer as more studies of early pregnancy are performed. It is the aim of this review to draw together our knowledge of events that occur to facilitate a successful pregnancy ranging from the preparation for implantation, through the invasion and differentiation of the trophoblast and the regulation of these processes by other cells within the decidual environment, to the active role that the trophoblast and maternal immune cells play in facilitating the remodelling of the uterine spiral arteries. The events involved in a healthy pregnancy will then be compared to aberrant placentation and remodelling, which are characteristics of many pregnancy disorders, and recent advances in detection of abnormal placental development will also be discussed. Reproduction (2010) 140 803-813
引用
收藏
页码:803 / 813
页数:11
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