Water-based biphasic media for exothermic reactions: green chemistry strategy for the large scale preparation of clofibric acid and analogues

被引：12

作者：

Bose, AK ^{[1
]}

Manhas, MS ^{[1
]}

Ganguly, SN ^{[1
]}

Pednekar, S ^{[1
]}

Mandadi, A ^{[1
]}

机构：

[1] Stevens Inst Technol, Dept Chem & Biol Chem, George Barasch Bioorgan Res Lab, Hoboken, NJ 07030 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 17期

关键词：

2-methyl-2-aryloxypropanoic acids; exothermic reaction; water-based biphasic reaction media; clofibric acid; energy-efficient process;

D O I：

10.1016/j.tetlet.2005.03.025

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A water-based biphasic reaction process has been developed for conducting exothermic reactions without organic solvents. This procedure is rapid, simple, and suitable for small scale synthesis as well as larger (multi-molar) scale reactions. The preparation of several hundred grains of clofibric acid and analogues by this eco-friendly and energy-efficient procedure is described. Smaller amounts of these compounds were prepared by the friction-activated 'Grindstone Chemistry' method described previously. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3011 / 3013

页数：3

共 7 条

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