An antimicrobial activity of cytolytic T cells mediated by granulysin

被引：833

作者：

Stenger, S

Hanson, DA

Teitelbaum, R

Dewan, P

Niazi, KR

Froelich, CJ

Ganz, T

Thoma-Uszynski, S

Melián, A

Bogdan, C

Porcelli, SA

Bloom, BR

Krensky, AM

Modlin, RL ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Med, Div Dermatol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Sch Med, Dept Med, Div Pulm Med, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Sch Med, Dept Microbiol & Immunol, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Sch Med, Inst Mol Biol, Los Angeles, CA 90095 USA

[5] Stanford Univ, Dept Pediat, Div Immunol & Transplantat Biol, Stanford, CA 94305 USA

[6] Albert Einstein Coll Med, Howard Hughes Med Inst, Bronx, NY 10461 USA

[7] Evanston NW Healthcare Res Inst, Evanston, IL 60201 USA

[8] Evanston Hosp Corp, Dept Med, Evanston, IL 60201 USA

[9] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02115 USA

[10] Univ Erlangen Nurnberg, Inst Klin Mikrobiol Immunol & Hyg, D-91054 Erlangen, Germany

来源：

SCIENCE | 1998年 / 282卷 / 5386期

关键词：

D O I：

10.1126/science.282.5386.121

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cytolytic T Lymphocytes (CTLs) kill intracellular pathogens by a granule-dependent mechanism. Granulysin, a protein found in granules of CTLs, reduced the viability of a broad spectrum of pathogenic bacteria, fungi, and parasites in vitro. Granulysin directly killed extracellular Mycobacterium tuberculosis, altering the membrane integrity of the bacillus, and, in combination with perforin, decreased the viability of intracellular M. tuberculosis. The ability of CTLs to kill intracellular M, tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intracellular pathogens.

引用

页码：121 / 125

页数：5

共 37 条

[1] NK-LYSIN, A NOVEL EFFECTOR PEPTIDE OF CYTOTOXIC T-CELLS AND NK-CELLS - STRUCTURE AND CDNA CLONING OF THE PORCINE FORM, INDUCTION BY INTERLEUKIN-2, ANTIBACTERIAL AND ANTITUMOR-ACTIVITY [J].