Inhibitory effect of oxcarbazepine on high-frequency firing in peripheral nerve fibers

被引:32
作者
Ichikawa, K
Koyama, N
Kiguchi, S
Kojima, M
Yokota, T
机构
[1] Kissei Pharmaceut Co Ltd, Pharmacol Res R & D, Nagano 3998304, Japan
[2] Shiga Univ Med Sci, Dept Physiol, Shiga, Japan
关键词
oxcarbazepine; excitation; repetitive; peripheral nerve; (animal);
D O I
10.1016/S0014-2999(01)01007-X
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
We assessed the effects of oxcarbazepine, an antiepileptic derivative of carbamazepine, on discharges in single cutaneous afferent fibers produced by repetitive high-frequency stimulation (mimicking the abnormal excitation of peripheral nerves in neuropathic pain and paresthesia). After intravenous administration of oxcarbazepine. the later responses in the train dropped our without the earlier ones being affected and, thus, the total number of spikes decreased. The latency of the responses to an individual pulse was unchanged. These results, which indicate that oxcarbazepine inhibits the generation of high-frequency firing without affecting impulse conduction, suggest that this drug may be useful against neuropathic pain and paresthesia. (C) 2001 Published by Elsevier Science B.V.
引用
收藏
页码:119 / 122
页数:4
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