Reversion of immune escape HIV variants upon transmission: insights into effective viral immunity

被引:36
作者
Kent, SJ [1 ]
Fernandez, CS
Dale, CJ
Davenport, MP
机构
[1] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia
[2] Univ New S Wales, Prince Wales Hosp, Dept Haematol, Sydney, NSW 2052, Australia
[3] Univ New S Wales, Ctr Vasc Res, Sydney, NSW 2052, Australia
关键词
D O I
10.1016/j.tim.2005.03.011
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Many viruses that cause chronic viremic infections, such as human immunodeficiency virus type 1 (HIV-1), mutate extensively to avoid effective control by the host immune system. However, each immune escape mutation probably results in some fitness cost to the virus. The most effective immune responses might be those that target the regions of the virus where escape mutation inflicts the largest fitness cost to the virus. A virus crippled by immune escape mutations would result in reduced viral load and delayed disease. Such knowledge could be used to rationally design more effective vaccines.
引用
收藏
页码:243 / 246
页数:4
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