A homo [3+2] dipolar cycloaddition: The reaction of nitrones with cyclopropanes

被引：293

作者：

Young, IS ^{[1
]}

Kerr, MA ^{[1
]}

机构：

[1] Univ Western Ontario, Dept Chem, London, ON N6A 5B7, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 26期

关键词：

cycloaddition; cycloalkanes; heterocycles; nitrones;

D O I：

10.1002/anie.200351573

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pole-to-pole: Cyclopropanediesters when treated with nitrones in the presence of catalytic ytterbium trifiate undergo a dipolar homo [3 + 2] cycloaddition to form tetrahydro-1,2-oxazines diastereoselectively (see scheme). This new process has been used in a two-step preparation of the tricyclic core of FR-900482.

引用

页码：3023 / 3026

页数：4

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