Rational Design of Multi-Stimuli-Responsive Nanoparticles for Precise Cancer Therapy

被引：235

作者：

An, Xiaonan ^{[1
]}

Zhu, Aijun ^{[2
]}

Luo, Huanhuan ^{[2
]}

Ke, Hengte ^{[2
]}

Chen, Huabing ^{[2
,3
,4
]}

Zhao, Youliang ^{[1
]}

机构：

[1] Soochow Univ, Suzhou Key Lab Macromol Design & Precis Synth, Jiangsu Key Lab Adv Funct Polymer Design & Applic, Coll Chem Chem Engn & Mat Sci,State & Local Joint, Suzhou 215123, Peoples R China

[2] Soochow Univ, Coll Pharmaceut Sci, Jiangsu Key Lab Translat Res & Therapy Neuropsych, Suzhou 215123, Peoples R China

[3] Soochow Univ, Jiangsu Higher Educ Inst, Collaborat Innovat Ctr Radiat Med, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215123, Peoples R China

[4] Soochow Univ, Sch Radiat Med & Protect, Suzhou 215123, Peoples R China

来源：

ACS NANO | 2016年 / 10卷 / 06期

基金：

中国国家自然科学基金;

关键词：

miktoarm star copolymer; multisensitive nanoparticles; synergistic effect; stimuli-triggered release; cancer therapy; PHOTOREMOVABLE PROTECTING GROUPS; DRUG-DELIVERY; VISIBLE-LIGHT; POLYMERIC MICELLES; THERMO-CHEMOTHERAPY; BLOCK-COPOLYMER; RELEASE; NANOCARRIERS; BODIPY; TUMOR;

D O I：

10.1021/acsnano.6b01296

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Stimuli-responsive nanoparticles with target capacity are of great interest in drug delivery for cancer therapy. However, the challenge is to achieve highly smart release with precise spatiotemporal control for cancer therapy. Herein, we report the preparation and properties of multi-stimuli-responsive nanoparticles through the co-assembly of a 3-arm star quaterpolymer with a near-infrared (NIR) photothermal agent and chemotherapeutic compound. The nanoparticles can exhibit NIR light/pH/reduction-responsive drug release and intracellular drug translocation in cancer cells, which further integrate photoinduced hyperthermia for synergistic anticancer efficiency, thereby leading to tumor ablation without tumor regrowth. Thus, this rational design of nanoparticles with multiple responsiveness represents a versatile strategy to provide smart drug delivery paradigms for cancer therapy.

引用

页码：5947 / 5958

页数：12

共 75 条

[1]

Two Colors of Light Are Needed to Break Bonds and Release Small Molecules from the Surface of SiO2-Au Core-Shell Nanoparticles [J].