Environmental risk factors for type 1 diabetes

被引：494

作者：

Rewers, Marian ^{[1
]}

Ludvigsson, Johnny ^{[2
,3
]}

机构：

[1] Univ Colorado, Sch Med, Barbara Davis Ctr Diabet, Aurora, CO USA

[2] Linkoping Univ, Fac Med, Dept Clin & Expt Med, Div Pediat, SE-58185 Linkoping, Sweden

[3] Linkoping Univ Hosp, SE-58185 Linkoping, Sweden

来源：

LANCET | 2016年 / 387卷 / 10035期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

CALMETTE-GUERIN VACCINATION; BETA-CELL AUTOIMMUNITY; HLA-CONFERRED SUSCEPTIBILITY; ENDOPLASMIC-RETICULUM STRESS; CAPSID PROTEIN VP1; EARLY WEIGHT-GAIN; ISLET AUTOIMMUNITY; ENTEROVIRUS INFECTION; DRINKING-WATER; GUT MICROBIOTA;

D O I：

10.1016/S0140-6736(16)30507-4

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The incidence of type 1 diabetes has risen considerably in the past 30 years due to changes in the environment that have been only partially identified. In this Series paper, we critically discuss candidate triggers of islet autoimmunity and factors thought to promote progression from autoimmunity to overt type 1 diabetes. We revisit previously proposed hypotheses to explain the growth in the incidence of type 1 diabetes in light of current data. Finally, we suggest a unified model in which immune tolerance to beta cells can be broken by several environmental exposures that induce generation of hybrid peptides acting as neoautoantigens.

引用

页码：2340 / 2348

页数：9

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