Impact of interictal epileptic activity on normal brain function in epileptic encephalopathy:: An electroencephalography-functional magnetic resonance imaging study

被引：23

作者：

De Tiege, X. ^{[1
]}

Harrison, S.

Laufs, H.

Boyd, S. G.

Clark, C. A.

Allen, P.

Neville, B. G.

Vargha-Khadem, F.

Cross, J. H.

机构：

[1] UCL Inst Child Hlth, Neurosci Unit, London, England

[2] UCL Inst Child Hlth, Dev Cognit Neurosci Unit, London, England

[3] Natl Soc Epilepsy, London, England

[4] UCL Inst Neurol, Dept Clin & Expt Epilepsy, London, England

[5] UCL Inst Child Hlth, Radiol & Phys Unit, London, England

[6] Great Ormond St Hosp Sick Children, Dept Clin Neurophysiol, London WC1N 3JH, England

[7] UCL Inst Neurol, Dept Clin Neurophysiol, London, England

来源：

EPILEPSY & BEHAVIOR | 2007年 / 11卷 / 03期

基金：

英国医学研究理事会;

关键词：

epilepsy; children; epileptic encephalopathy; cognition; behavior; electroencephalography-functional magnetic resonance imaging;

D O I：

10.1016/j.yebeh.2007.06.001

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 [法学]; 0303 [社会学]; 030303 [人类学]; 04 [教育学]; 0402 [心理学];

摘要：

Using electroencephalography (EEG) in combination with functional magnetic resonance imaging (fMRI, we studied a 9.5-year-old girl who developed cognitive and behavioral regression in association with intense interictal bilaterally synchronous epileptic discharges (IBSEDs) both during the awake state and during sleep. During runs of IBSEDs, EEG-fMRI demonstrated deactivations in the lateral and medial frontoparietal cortices, posterior cingulate gyrus, and cerebellum together with focal relative activations in the right frontal, parietal, and temporal cortices. The deactivations probably reflect the repercussion of the interictal epileptic activity on normal brain function which might cause the neuropsychological regression by inducing repetitive interruptions of neurophysiological function resulting, in a chronic state of specific psychomotor impairment. The relative activations could possibly indicate the source of epileptic activity rapidly spreading to other brain regions. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：460 / 465

页数：6

共 19 条

[1]

Effects of epileptiform EEG discharges on cognitive function: Is the concept of "transient cognitive impairment" still valid? [J].