Gene of the month: HGF

被引：57

作者：

Fajardo-Puerta, Ana Belen ^{[1
]}

Prado, Mireia Mato ^{[2
]}

Frampton, Adam E. ^{[1
,2
]}

Jiao, Long R. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, HPB Surg Unit, Hammersmith Hosp Campus,Du Cane Rd, London W12 0HS, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, Div Canc, Hammersmith Hosp Campus,Du Cane Rd, London W12 0HS, England

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2016年 / 69卷 / 07期

关键词：

HEPATOCYTE GROWTH-FACTOR; FACTOR SCATTER FACTOR; C-MET PROTOONCOGENE; EPITHELIAL MORPHOGENESIS DOWNSTREAM; RECEPTOR TYROSINE KINASE; HEPATOCELLULAR-CARCINOMA; LIVER-REGENERATION; COLORECTAL-CANCER; SIGNALING PATHWAY; EXPRESSION;

D O I：

10.1136/jclinpath-2015-203575

中图分类号：

R36 [病理学];

学科分类号：

100103 [病原生物学];

摘要：

Hepatocyte growth factor (HGF) is a multifunctional cytokine with important roles in cell proliferation, survival, motility and morphogenesis. Secreted by cells of mesenchymal origin, HGF is the specific ligand for the tyrosine-kinase receptor c-MET (cellular mesenchymal-epithelial transition), also called MET, which is expressed in different types of epithelial, endothelial and haematopoietic progenitor cells. The HGF/MET axis is involved in several biological processes, such as embryogenesis, organogenesis, adult tissue regeneration (including wound healing and liver regeneration) and carcinogenesis, for both solid and haematological malignancies. 1 2 HGF and its particular interaction with the MET receptor have been extensively investigated in the last decades and remain the focus of numerous clinical trials. 3-8 This short review focuses on HGF structure and function, as well as its roles in liver regeneration and different types of tumours.

引用

页码：575 / 579

页数：5

共 94 条

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