Formation of 4-aminopyrimidines via the trimerization of nitriles using focused microwave heating

被引：32

作者：

Baxendale, IR ^{[1
]}

Ley, SV ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2005年 / 7卷 / 03期

关键词：

D O I：

10.1021/cc049826d

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A series of substituted aliphatic nitriles have been trimerized to their corresponding pyrimidine structures under solvent-free conditions in the presence of catalytic quantities of potassium tert-butoxide using a focused microwave reactor. Multigram quantities of the corresponding 4-aminopyrimidines have been prepared in high yields and purity following a simple and scaleable protocol.

引用

页码：483 / 489

页数：7

共 55 条

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