Randomized trial of adjuvant chemotherapy versus central after curative resection for gastric cancer: 5-year follow-up

被引：50

作者：

Neri, B ^{[1
]}

Cini, G

Andreoli, F

Boffi, B

Francesconi, D

Mazzanti, R

Medi, F

Mercatelli, A

Romano, S

Siliani, L

Tarquini, R

Moretti, R

机构：

[1] Univ Florence, Dept Internal Med, I-50121 Florence, Italy

[2] Univ Florence, Oncol Day Hosp, I-50121 Florence, Italy

[3] Univ Florence, Dept Gen Pathol & Expt Oncol, I-50121 Florence, Italy

[4] Univ Florence, Inst Gen Surg, I-50121 Florence, Italy

[5] Careggi Hosp, Dept Surg, Florence, Italy

[6] Civ Hosp, Dept Surg, Viareggio, Italy

[7] Univ Florence, Dept Clin Physiopathol, I-50121 Florence, Italy

来源：

BRITISH JOURNAL OF CANCER | 2001年 / 84卷 / 07期

关键词：

adjuvant chemotherapy; epidoxorubicin; 5-fluorouracil; gastric cancer; leucovorin; randomized trial;

D O I：

10.1054/bjoc.2000.1472

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adjuvant chemotherapy of gastric cancer after curative resection is still subject to discussion. In this study 137 patients with gastric adenocarcinoma, all with positive nodes, were randomized after curative resection so that 69 received epidoxorubicin (EPI), leucovorin (LV) and 5-fluorouracil (5-FU) on days 1-3 every 3 weeks for 7 months, whereas the remaining 68 did not, After a follow-up period of 5 years, 21 of the 69 treated patients (30%) and nine controls (13%) were still alive; median survival time was 18 months for the controls and 31 months for the patients treated with adjuvant chemotherapy (P < 0.01). (C) 2001 Cancer Research Campaign.

引用

页码：878 / 880

页数：3

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